Endocrine Abstracts

Background: There is some evidence suggesting an interaction between renin-angiotensin-aldosterone system and parathyroid hormone (PTH). Decreased aldosterone levels after parathyroidectomy have been reported in patients with primary hyperparathyroidism (PHPT). Recently, most of the diagnosed patients with PHPT are mild or asymptomatic. Our aim was to investigate plasma aldosterone and renin concentrations in patients with asymptomatic PHPT.Methods: Thir...

Objective: Cushing’s syndrome (CS) is related to diabetes mellitus, dyslipidaemia, hypertension, and obesity, which lead to cardiovascular disease (CVD). CVD is the major cause of mortality and morbidity in CS. The aim of our study was to investigate CVD risk markers, such as asymmetric dimethylarginine (ADMA), lipoprotein-associated phospholipase A2 (Lp-PLA2), highly sensitive C-reactive protein (hsCRP), homocysteine, lipid levels, ankle-brachial index (ABI), and carotid...

Introduction: Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging, skin changes, gray hair, alopecia, muscle atrophy, osteoporosis, and cataracts and has a high frequency of association with rare neoplasms. In addition, some endocrinological abnormalities were manifested in this rare disease, such as hypogonadism, diabetes mellitus, hyperlipidemia. Atrophic changes of organs and systems such as skin, brain and genital organs were reported. H...

Introduction: Thyroid lymphoma is a rare disease. Furthermore, coincidence of extrathyroidal lymphoma is very rare.Case: A 69 years-old woman patient was admitted to the hospital with dyspnea, hoarse voice and swelling of throat for a month. In her history, she had been diagnosed as gastric lymphoma 6 years ago, while she was being investigated for upper gastrointestinal bleeding. Six cures of chemotherapy has been applied. She was not on follow up. In p...

‘Nondippers’ are individuals with absence of anticipated nocturnal decrease in blood pressure (BP) and increased incidence of target organ damage. The pathogenesis of nondipper hypertension is not clear at present. We aimed to investigate the effect of overt and subclinical hypothyroidism on the development of nondipper blood pressure pattern via 24-hour ambulatory blood pressure monitoring. One hundred and nine normotensive patients with overt and subclinical hypoth...

Endocan has been suggested as a marker for endothelial dysfunction. Some evidence exists that Graves’ disease may be associated with impaired endothelial function. The aim of the study was to evaluate serum endocan, endothelial growth factor (VEGF) and carotid intima media thickness (CIMT) in patients with Graves’ disease. Thirty one newly diagnosed patients with Graves’ disease and 31 healthy volunteers with similar age and sex were examined. Serum endocan, VEG...

Aim: Sleep disturbances are widespread and closely associated with pituitary diseases, even those under long-term therapeutic management. The aim of this study was to investigate sleep quality, depression, anxiety, and physical activity in patients with non-functioning pituitary adenoma (NFPA) and determine the factors that might be associated with decreased quality of sleep.Method: Eighty-two patients with NFPAs and 82 age- and gender-matched control su...

Metastatic infiltration of the adrenal glands is a common finding of malignancies, but few case reports showed primary adrenal insufficiency being the presenting manifestation of underlying malignant tumors. Here, we report a case of adrenal insufficiency secondary to metastases from lung adenocarcinoma.A 69-year-old man was admitted to emergency department with weakness, altered mental status, hypotension, fever and weight loss. He had 100 pack-year his...

Hyperthyroidism whether endogenous or exogenous in origin causes hemodynamic changes which associated with adverse cardiovascular outcomes. Ambulatory arterial Stiffness index (AASI) is a non invasive way of measuring arterial stiffness. Short term BP variability is derived from 24-hour ambulatory blood pressure monitoring (ABPM) recordings. BP variability and AASI are associtaed with increased cardiovascular risk.We aimed to investigate AASI and short t...

Idiopathic granulomatous hypophysitis is a very rare inflammatory disease of the pituitary gland. Primary hypophysitis represents a difficult diagnostic challenge because it can imitate pituitary adenomas clinically and radiologically. The diagnosis is usually made histologically by hypophysectomy. We herein present a rare case of idiopathic granulomatous hypopysitis diagnosed primarily by pituitary biopsy.Case: A 50-year-old female patient presented wit...